By Tim Friend
Tues., Feb. 17, 1998
FINAL EDITION
Section: NEWS
Page 1A
PHILADELPHIA -- The most common strain of bacteria in dental plaque can cause
blood clots that induce heart attacks when they escape into the bloodstream,
researchers reported Monday.
Mark Herzberg of the University of Minnesota said the findings are the first
to link bacteria to the formation of potentially fatal blood clots.
Previous studies had found the incidence of heart disease is about twice as
high in people with periodontal disease, but scientists didn't know why.
``Now we show a potential biological reason,'' Herzberg told the 150th annual
meeting of American Association for the Advancement of Science.
In lab tests, Herzberg and colleagues injected bacteria from dental plaque
into the bloodstream of rabbits. The bacteria caused blood clots to form within
minutes. Rabbits are a proven model for testing hypotheses about human heart
disease and heart attacks.
Chronic inflammation of the gums due to plaque also could be involved in the
inflammation of the lining of the blood vessels that is known to lead to the
build-up of plaque in the arteries, Herzberg said.
Additional studies presented at the meeting show that bacteria in plaque also
are linked to: